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HISTOPATHOLOGICAL, BIOCHEMICAL AND HAEMATOLOGICAL CHANGES OF NALBUPHINE-HCL ADMINISTRATION ON LIVER OF ALBINO RAT.

Nalbuphine-HCl is a semi-synthetic opioid agonist-antagonist used commercially as an analgesic under a variety of trade names, including Nubain and Manfine. Nalbuphine-HCl considers one of the widely used opioids in recent years is an effective analgesic agent for the treatment of moderate to severe pain. So, this study was designed to study toxicity of Nalbuphine-HCl on liver. The animals were divided into four groups, twenty animals in each group. The treated groups were injected with the analgesic, double and tribal doses with Nalbuphine-HCl, respectively. The negative group animals were injected only with the same of saline (0.9% NaCl). The main histopathological findings were showed inflammatory cellular infiltration, dilated congested blood vessels, hydropic degeneration, and fibrotic regions around the proliferated bile ducts. Also, pyknotic and karyolitic nuclei were detected. In addition, the biochemical results of the liver function (AST, ALT and ALP) and the hematological investigation (Hb, RBC HCT and the platelets cells) revealed a marked decrease in liver enzymes and hematological parameters, which were parallel to the histopathological changes after the treatment with all doses of Nalbuphine-HCl.



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Keywords: Liver Histopathology Nalbuphine-HCL Opioids Liver enzymes Hematological parameters.

ISSN: 2320-5407

EISSN: 2320-5407


EOI/DOI: http://dx.doi.org/10.21474/IJA


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