An easy, precise, sensitive, reproducible, cost-effective spectroscopic method was developed and validated for the estimation of Clarithromycin. This method obeys Beer’s Law in concentration ranges of 0.1-0.8 mg.mL?1for Clarithromycin. This method was validated for parameters including linearity, accuracy, precision and ruggedness as per ICH guidelines. The ? max of Clarithromycin was 205 nm in methanol. The drug follows linearity in the concentration range 0.1-0.8 mg.mL?1 with a correlation coefficient value of 0.995. The accuracy of this method was tested by recovery method implemented at three different levels, i.e., 120%, 100%, and 80%. Precision of method was studied as an intra-day; inter-day variations & repeatability. The %RSD value is less than 2% (< 2) which indicates that the method is precise. Ruggedness of method was studied with the aid of two different analysts. This developed and validated method can be adopted/ recommended for the routine quality control and quantitative analysis of Clarithromycin.
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Author Name: Zehra Ashraf, Somia Gul and Faazia Qaazi
URL: View PDF
Keywords: Clarithromycin, Method Determination, Spectroscopy, UV, Validation
ISSN:
EISSN: 2249 –1929
EOI/DOI: Nil
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