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EVALUATION OF ANTINEPHROLITHIC ACTIVITY OF BENINCASA HISPIDA (THUNB) COGN. IN WISTAR ALBINO RATS AGAINST ETHYLENE GLYCOL INDUCED NEPHROLITHIASIS.

Purpose: To evaluate the activity of Nephrolithic of the aqueous and ethanolic extracts of Benincasa hispida (Thunb.)COGN seeds against ethylene glycol induced Nephrolithiasis in albino rats. Methods: Nephrolithiasis was induced by oral administration of ethylene glycol (0.75 % v/v) in male albino rats for 28 days. The ethanolic and aqueous extracts of seeds of Benincasa hispida (250 & 500 mg/kg) were administered orally from the 28 days as a curative regimen urine analysis; serum analysis and histopathological study were performed. Results: The body weight changes were noted EG treated animals shown marked weight loss when compared to control. Treated groups like cystone at dose level of 750 mg/kg body weight, EESBH and Aq. ESBH at dose levels of 250 and 500 mg/kg body weight showed marked recovery in weight loss when compared to EG treated group. The urine volume, urine were decreased as well as oxalates, calcium, phosphorus, sodium and potassium excretion in urine, serum urea, uric acid, creatinine and BUN contents were increased in lithiatic group as compared to normal control group. Treatment with both ethanolic and aqueous seed extracts restored urine volume, oxalates, calcium, phosphorus, sodium and potassium levels. Histopathological examination revealed tubular degeneration, dilatation, presence of CaOx crystals in the lumen of renal tubules and intense interstitial mononuclear cell infiltration in the lithiatic control group. These histopathological alterations were markedly regressed in other treated groups. Conclusions: The results demonstrate that the ethanolic and aqueous extracts of Benincasa hispida seeds have potent anti-nephrolithiatic activity against nephrolithiasis induced by ethylene glycol in wistar albino rats.



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Keywords: Nephrolithic Kidney Stones Ethylene glycol Benincasa hispida

ISSN: 2320-5407

EISSN: 2320-5407

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