State of hyperglucocorticoidemia was modeled in experimental rats by administration of dexamethasone for 14 days. In the liver and kidneys of the animals disorders of the functional state of methylation and transsulfuration pathways enzymes (S-adenosyl methionine synthetase, S-adenosyl homocysteine hydrolase, betaine homocysteine methyl transferase, cystathionine-?-synthase and cystathionine-?-lyase) occurred, which led to an increase in serum homocysteine. Folic acid, cyanocobalamin, pyridoxine and betaine, when introduced in parallel with dexamethasone, partly prevented disorders of methylation and transsulfuration processes and normalized the homocysteine level in blood.
Real Time Impact Factor:
1
Author Name: NECHYPORUK V., KORDA M.
URL: View PDF
Keywords: hyperglucocorticoidemia, methylation and transsulfuration processes, homocysteine, vitamin B9, B12, B6, betaine.
ISSN: 1609-6371
EISSN: 2415-3176
EOI/DOI:
Add Citation
Views: 1
