In experiments on white rats the phase character of change of the condition of
synaptic transmission in the frontal tibial muscle in dynamics of chronic injection of
dexamethasone has been shown: after 5 injections of dexamethasone the latent period
of muscle’s excitation has been shortened, whereas after 10 injections — it has come
back to the control level, after 15–25 injections it has extended, and after 30 injections
of a hormone it has normalized again. At the same time, reliability of neuromuscular
transmission has been decreased after 10 injections of dexamethasone and has remained
lowered during all period of its further injection in to the organism.
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Author Name: Trush V.
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Keywords: dexamethasone, hypercortisolism, neuromuscular transmission, latent period of muscular excitation.
ISSN: 1609-6371
EISSN: 2415-3176
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