The purpose of this study is to develop a novel liquid-solid technique to enhance the dissolution rate of poorly water soluble drug Pitavastatin, which is a BCS class II drug. Liquid-solid system refers to the formulations that are formed by conversion of liquid drugs, drugs suspensions or solution in non-volatile solvents into dry, non-adherent, free flowing and compressible powder mixture. Hence the dissolution step, a pre-requisite for drug absorption, is bypassed and better bioavailability of porrly soluble drug is achieved. Liquidsolid tablets were prepared by using PEG-400 as non volatile liquid vehicles and Avicel PH 102, Aerosil as carrier and coating materials respectively. All the formulations wrere evaluated for disintegration time, hardness, friability and in-vitro dissolution study. Among all the formulation LS10 was considered to be the best formulation, which released upto 99.5% of the drug in 20 minutes.
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Author Name: B.ANUHYA*, A.SEETHA DEVI
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Keywords: Pitavastatin, Cross Carmellose Sodium, Aerosil, Avicel, Disintegration time,FT-IR.
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EISSN: 2231- 0541
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