The enzymes Renin and Aniotensin Converting Enzymes (ACE’s) are key enzymes associated with blood pressure, congestive
heart failure and diabetic nephropathy. Renin is a protease, prohormone acting on free floating angiotensinogen. Three kinds of
ACE’s namely (ACE, ACE2 ACET (Testicular)) in humans, are carboxy peptidases, membrane bound, one of the receptors of
insulin, participating in signal transduction convertsf Angiotensin I to Angiotensin II, a potent vaso constrictor raising blood
pressure. This study was proposed with the aim to identify herbal inhibitors for these enzymes. The herbals zinger and Pausinystalia
yohimbe were selected as herbal inhibitors, contains alkaloids zingeberene and yohimbine. The 3D structure of the enzymes were
predicted using Swiss model server and the target sites identified using Thematics server. The chemical structure of the ligands and
peptide structure of the target sequences drawn using Argus lab software and then converted into Protein Data Bank (PDB) format.
Finally the targets and ligands were docked using Hex software. Docking results on this ligands indicated that the ligands has a
potency to bind to the target sites on the enzymes. The proposed, herbal inhibitors has shown all the desirable features of a potent
inhibitor and hence it may be a potential lead compound.
Real Time Impact Factor:
Pending
Author Name: Sampoornam Balakrishnan, Shila Samuel
URL: View PDF
Keywords: herbal inhibitor, protein engineering, drug discovery, drug design, protein-protein interaction, nano technology, signal transduction
ISSN: 2454-9142
EISSN: 2454-9142
EOI/DOI:
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