Malaria has become the public health concern worldwide. Although it is preventable and curable; P. falciparum and P. vivax have
developed resistance to nearly all anti-malarial in current use.
New drug discovery and novel drug leads are required to control the current malaria disease burden. The inventor has developed
malaria nosode and has subjected it for evaluation of antimalarial activity in vitro assay along with few other homeopathy
preparations.
The potential antimalarial activity of the Malaria nosode, Malaria officinalis and China officinalis was evaluated by ?-Hematin
Formation Assay. The hemozoin content was determined by measuring the absorbance at 400 nm. The results were recorded as %
inhibition of heme crystallization compared to negative control (DMSO)
Malaria nosode, Malaria officinalis and China officinalis exhibited inhibition of hemozoin and the inhibition was greater than the
positive control Chloroquine diphosphate used in the study.
The study has shown anti-disease activity of an ultra-dilute (potentized) homeopathic preparation. The Malaria nosode prepared by
potentizing Plasmodium falciparum organisms has demonstrated antimalarial activity, which supports the basic principle behind
homeopathy, the law of similar.
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Author Name: Samidha Joshi, Renuka Munshi, Gitanjali Talele, Rajesh Shah
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Keywords: malaria, P. falciparum, nosode, in vitro activity, hematin, hemozoin, homeopathy
ISSN: 2454-9142
EISSN: 2454-9142
EOI/DOI:
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