Aim: Acute appendicitis is the most common acute condition of the abdomen requiring surgery. To
date, several inflammatory markers have been used for the diagnosis of acute appendicitis. The aim of
this study was to evaluate the diagnostic utility of CA-125 (cancer antigen 125) in acute appendicitis.
Methods: We prospectively enrolled 52 consecutive male patients and 20 healthy control subjects.
Results: Overall, 48/52 patients had acute appendicitis. Of these, 17 had complicated appendicitis
(35%). The CA-125 concentration was significantly greater in patients with acute appendicitis than in
healthy subjects (26.3 vs. 9.6 U/mL, P < .001). CA-125 concentrations were not significantly different
between patients with complicated appendicitis or uncomplicated appendicitis (P > .017). Receiver
operating characteristic curve analysis suggested that the optimal cutoff CA-125 concentration for acute
appendicitis diagnosis was 11.78 U/mL. The positive predictive value and the negative predictive
values were 91.0% (95% confidence interval 78.14%–97.52%) and 66.6% (95% confidence interval
44.62%–84.33%), respectively.
Conclusions: We conclude that measurement of CA-125 concentration may support the clinical
diagnosis of acute appendicitis.
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Author Name: Ismail Bilgic, Tamer Durdu, Sibel Gelecek, Sukru Yorulmaz, Evvah Karakilic, M. Mahir Ozmen, Cemil Kavalci
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Keywords: CA-125, acute appendicitis, inflammation
ISSN: 2349-4182
EISSN: 2349-4182
EOI/DOI:
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