Mixing organophosphate (OP) and pyrethroid (PYR) insecticides becomes common in Egypt since mid-1980s and result in an impairment of male reproductive function. The present investigation was conducted to study certain criteria used to evaluate the reproductive toxicity of treated male rats with the commercial preparation of OP/PYR mixture, namely Runsave, which contains 30% chlorpyrifos (CPF) and 3% lambda-cyhalothrin (LTC) compared to its individual commercial components of 48% E.C (CPF) and 5% E.C (LTC). Adult male rats were treated dermally with sublethal dose of each toxicant (6 rats each) on alternate day for 8 weeks, then they were sacrificed except few rats that treated with Runsave mixture. The relative testes weights, semen picture, activities of plasma and brain cholinesterases as well as histopathological changes in testes were determined. The remaining rats that treated with Runsave were allowed to mate with untreated adult females. Results showed that the candidate toxicants brought about marked reduction in testes relative weights, sperm counts and motilities, activities of plasma and brain cholinesterases (ChEs) and caused histopathological alterations in testes of treated rats, all in comparison with those of corresponding control group. Generally, the commercial preparation Runsave has potentially greater toxic impact for rats than its components alone. Male rats treated with Runsave and allowed to mate with receptive untreated females, their reproductive capabilities were greatly diminished.

Author Name: Naser A. Al-Ansary; Fouad A. F. Ali; Mohamed F. El-Tawil; Emad M. Marzouk

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Keywords: Organophosphate and Pyrethroid insecticides mixture; dermal exposure; Cholinesterases; reproductive capacity; semen picture; histopathological changes in albino rats

ISSN: 2090-0791

EISSN: 2090-0864

EOI/DOI: 10.21608/EAJBSF.2016.17131

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