Alzheimer’s disease (AD) is a progressive neurodegenerative disease with deteriorating memory loss in the aged population. Currently, its exact pathogenesis remains elusive. Some studies have shown that soluble oligomeric A? (?-amyloid), inducing hyperphosphorylation of tau, may be the initial link to AD pathogenesis. However, it is poorly known how A? influences tau phosphorylation; Results, in this study, soluble oligomeric A?42 peptide was injected into the hippocampus of mice with saline as a control. Hematoxylin and eosin (HE) staining showed that A?42 was mainly deposited in the Cornu Ammonis area 1 (CA1). Within 7 to 21 days after the operation, the area of A?42 decreased gradually. Compared to the control, the expression of phosphorylated tau (p-tau) was significantly increased, suggesting that soluble A? oligomers activated phosphorylation of tau and increased total tau. Meanwhile, we found that elevated Cdk5, mainly in the CA1 area and subgranular zone (SGZ), correlates with increased phosphorylation of tau. Conclusions, thus, the results suggest that hyperphosphorylation of tau induced by soluble amyloid A? is associated with an increased level of Cdk5.

Author Name: Guoying Li

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Keywords: Alzheimer’s disease; ?-amyloid; tau; Cdk5

ISSN: 2379-7150

EISSN: _

EOI/DOI: https://sciforschenonline.org/

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