GST (glutathione S-transferases) are a family of detoxification enzymes that catalyze the conjugation of reduced GSH (glutathione) to xenobiotic (endogenous electrophilic) compounds. GST from Wb (Wuchereria bancrofti) and Bm (Brugia malayi) are significantly different from human GST in sequence and structure. Thus, Wb-GST and Bm-GST are potential chemotherapeutic targets for anti-filarial treatment. Comparison of modeled Wb and Bm GST with human GST show structural difference between them. Analysis of the active site residues for the binding of electrophilic co-substrates provides insight towards the design of parasite specific GST inhibitors
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Author Name: Rayavarapu Bhargavi, Siddharth Vishwakarma, Upadhyayula Suryanarayana Murty
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Keywords: Filarial parasites; GST (glutathione-S-transferases); homology modeling; structural deviations; active site residues
ISSN: 0973-2063
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EOI/DOI: 10.6026/001000012005
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