Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate
cancer increase dramatically in several oriental countries including China. Rapidly evolving technology in molecular biology
such as high-throughput sequencing and integrative analysis of genomic and transcriptomic landscapes have enabled the identification of key oncogenic events for prostate cancer initiation, progression and resistance to hormonal therapy. These surging
data of prostate cancer genome also provide insights on ethnic variation and the differences in histological subtype of this disease. In this review, differences in the incidence of prostate cancer and the prevalence of main genetic alterations between
Asian and Western populations are discussed. We also review the recent findings on the mechanisms underlying neuroendocrine differentiation of prostate cancer and the development of small cell neuroendocrine carcinoma after androgen deprivation
therapy.
Real Time Impact Factor:
2.66667
Author Name: Yang Zong,ÿAndrew S. Goldstein,ÿJiaoTi Huangÿ
URL: View PDF
Keywords: 16747305,The molecular basis for ethnic variation and histological subtype differences in prostate cancer,16747305,Yang Zong,ÿAndrew S. Goldstein,ÿJiaoTi Huangÿ,The molecular basis for ethnic variation and histological subtype differences in prostate cancer,16747305,Yang Zong,ÿAndrew S. Goldstein,ÿJiaoTi Huangÿ
ISSN: 16747305
EISSN:
EOI/DOI:
Add Citation
Views: 4012