Osteoarthritis is a chronic degenerative disorder that currently represents one of the main causes of disability within the elderly population and an important presenting complaint overall. Osteoarthritis is the most common form of arthritis, affecting millions of people worldwide. It occurs when the protective cartilage that cushions the ends of your bones wears down over time. Osteoarthritis (OA) is caused by aging joints, injury, and obesity. Aim of the study was to determine the clinical efficacy and safety of glucosamine phosphate and to evaluate the chemically related methylsulfonylmethane (MSM), collagen peptide, Hyaluronic acid, Curcuma, Boswellia serrata, piperin, in the treatment of OA to determine their efficacy and safety profile. in the management of vitamin c osteoarthritis. Studies were included if they met the following criteria, studies about primary hip and or knee OA patients with clinical and or radiologic diagnosis, studies of glucosamine, chondroitin, (MSM), collagen peptide, Hyaluronic acid, Curcuma, Boswellia serrata, piperin, or the two in combination against placebo, extractable data reporting the pain, function, stiffness, and the adverse events (AEs) of patients. A (vital signs, physical examination, pregnancy test, previous medical history, chest X-ray, electrocardiogram, urine examination, serology, haematological and biochemical parameters) The exclusion criteria were as follows, treatment methods described unclearly, studies of non-randomized or uncontrolled trials, interventions combined with non-steroidal anti-inflammatory drugs, studies or data reported repeatedly, and trial arms with sub-therapeutic doses. For each study, patients’ characteristics including mean age, sex, mean duration of symptom, BMI, duration of follow-up, type of outcome (pain, function, stiffness, and AEs), trial design, trial size, details of intervention, treatment duration, and results were individually extracted. Data of intention-to-treat analysis was employed whenever possible. The primary outcomes of this were pain intensity, function improvement. Out of 68 patients with osteoarthritis diagnosis admitted to emergency department in our center, age range was from 21 to 75 years. About 45% of patients were female, and 55% were male. Severe Joint stiffness and Tenderness were the most prevalent manifestations that were present in patients. Glucosamine showed effect on stiffness outcome relieving pain and improving physical function. The data from the more rigorous MSM trials provide positive evidence in the treatment of mild to moderate OA of the knee. Chondroitin sulfate (CS) is recommended as a therapeutic intervention in the multimodal approach of osteoarthritis (OA) management. Hyaluronic acid is a potential bright spot for helping lower the side effects. Vitamin C might protect against the development of osteoarthritis, rheumatoid arthritis, and inflammatory polyarthritis, according to some studies. A powerful antioxidant, it fights molecules that trigger inflammation. It reduces pain and improves physical functioning significantly in OA patients; and it is safe for human consumption. It may exert its beneficial effects by controlling inflammatory responses through reducing proinflammatory modulators, and it may improve joint health by reducing the enzymatic degradation of cartilage in OA patients.
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Author Name: Dr. M. Sampoorna, Madugula Mahender & Srirangapurapu Vijaya Bhavani
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Keywords: Curcuma, Turmeric, Osteoarthritis, Dietary Supplements, Cartilage, Chondrocyte, Curcuma, Inflammation, Joint, Pain.