The purpose of the work is to mask the metallic taste of Ramipril with mannitol by cogrinding
method and to formulate it as an oral disintegrating tablet by the direct
compression method. Drug-Mannitol complexes were taken in 1:1, 1:1.5 and 1:2 ratios and
tested for in vitro and in vivo bitter masking capacity of mannitol, drug content and
molecular property. Different super-disintegrants like croscarmellose, sodium starch
glycolate and crospovidone was used as disintegrating agents. The prepared tablets were
characterized for tensile strength, wetting time, water absorption ratio, and In vitro and in
vivo disintegration time. In addition, aspartame is used as a sweetening agent which gives
a more pleasant taste in the mouth. Among all the formulations F1 to F6, Formulation F6
has good taste masking capacity and fast disintegration within 40sec. Furthermore, 96.7%
of the drug has been released in 15min.The results disclosed that the productivity of taste
masking of the drug has been done effectively with mannitol and 40mg of crosscarmellose
sodium is efficient for rapid disintegrating of the tablet
Real Time Impact Factor:
Pending
Author Name: K. USHA SRI*, bAJAYKUMAR.B, c K.VARUNKUMAR, d R.GEETHIKA
URL: View PDF
Keywords: Taste masking, Ramipril, Mannitol, Super disintegrants, rapid disintegrating tablets.
ISSN:
EISSN: 2231- 0541
EOI/DOI:
Add Citation
Views: 2818