The kinetics of oxidation of Ethambutol [EMB] by Chloramine-B [Sodium N-Chlorobenzene Sulfonamide,CAB] has
been studied in HCl medium with Ru(III) as catalyst at 313 K. The oxidation follows complex kinetics, the order with
respect to [CAB], and [HCl] each being unity, fractional order with Ru(III) and inverse first-order in [EMB], the solvent isotope effect was studied using D2O. Variation of ionic strength and addition of the reaction product had no effect on the reaction rate. However, the reaction rate
increased with decrease in dielectric constant of the medium. The effect of temperatue on the oxidation rate is studied and thermodynamic
parameters for catalysed oxidation are evaluated. The observed kinetic data suggest a possibility of oxidation reaction proceeding through
a complex formation between Ru(III) and EMB which reacts with the oxidizing species derived from CAB results in the final products. The
oxidation products formed are confirmed. The rate equation is derived and a possible reaction mechanism is proposed.
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Author Name: Nanda N, Puneeth Kumar
URL: View PDF
Keywords: Kinetics, Oxidation, Ethambutol, Chloramine-B.
ISSN: 2277-8179
EISSN: 2277-8179
EOI/DOI: 10.15373/22778179
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