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COMPARATIVE ANALYSIS OF THE IMPACT OF RETABOLIL, DERIVED TIOPIRANOTIAZOLU (SUBSTANCE LES-2222) AND TESTOSTERONE PROPIONATE ON PROTEIN METABOLISM IN THE BODY OF RATS AT FOOD DEPRIVATI

To study the effect Retabolilum derivative tiopiranotiazolu (Compound LES-2222) and testosterone propionate to the protein content in blood serum, tissues, organs and muscle in rats of food deprivation formed 5 groups of animals, 6 animals each: control received I-complete diet , II-exposed control of food deprivation for 9 days with free access to water; The experimental animals against the backdrop of food deprivation to apply these pharmacological agents that are administered daily also for 9 days. Established that food deprivation leads to a decrease of total protein in organs and tissues compared to intact, and the substrates investigated - to increase total protein, with the highest index value is set when entering substances LES-2222 in rats compared to similar other groups. Thus, the total protein content of rat serum testosterone propionate and use retabolil compared to the control group II animals was higher, respectively, 2.7 and 5.7%, and for the use of substances LES-2222 - 7.6% . In rat liver tissue indicators of total protein under conditions of food deprivation differed, but the value of the index was higher: for actions retabolil 11.7%, substance LES-2222 - 20.4% and testosterone propionate - 14.0%. Analysis of the relationship of total protein in the liver tissue of the conditions of research indicates the average power correlation (?2 = 0,314). The smallest decrease of total protein in rat spleen tissue found in the application of substances LES-2222. However, as the analysis of the results of the effects of research on the content of total protein in spleen tissue between them there is a weak correlation (? 2 = 0,128). The use of testosterone propionate and substance LES-2222, against the backdrop of food deprivation inhibits catabolism processes in the kidney tissue, providing higher value content of soluble proteins. Established research results confirmed dependence on the conditions of the research content of soluble proteins in kidney tissue of rats: correlation of medium strength (?2 = 0,479). The introduction of substances with anabolic effect, against food deprivation, provides higher levels of total protein in testis by using retabolil 24.4%, substance LES-2222 and testosterone propionate, respectively, 21.4 and 22.4%, compared Breakfast II controls. As the analysis of the results of research content of soluble proteins testis tissue depends on the conditions for research and value of the index is correlated with the average power (?2 = 0,329). Installed difference between the values of the average values of the content of soluble proteins in the tissues of the heart muscle is within the statistical error of the mean and was unlikely, and skeletal muscle tissue under conditions of food deprivation, the use of these substances leads to a tendency to increase the concentration of soluble proteins by the action of testosterone propionate 20.4% for retabolil 22.4% and substance LES-2222 26.5% than in animals for food deprivation For the first time the impact of derivative tiopiranotiazol (substances LES-2222) on the performance of protein metabolism in rats.



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Keywords: protein metabolism, anabolic action, food deprivation, retabolil, testos - terone propionate, tiopiranotiazolu derivative (substance LES-2222)

ISSN: 1609-6371

EISSN: 1609-6371

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