The aim of the study was to reduce the frequency of perinatal loss in women with premature births and hormonal dysfunction backdrop background genitalia by improving and developing pathogenetic predefined approaches to treatment and correction of profilactic adaptive capacity of functional systems responsible for the establishment and development of placenta. The analysis of clinical-statistical features of pregnancy flow, births and being of embrion is conducted in 160 pregnant women not with donoshouvannyam on a background treated fertility of endocrine genesis. It is established that the primary form of placental insufficiency which is most unfavorable in relation to stopping of pregnancy and breaking of her beating in early terms, characteristic for pregnancy at women which suffered by hypothalamic-hypophyseal insufficiency that hypergonadotropic amenorrhea. At the same time development and progress of placental insufficiency within the late periods of pregnancy characteristic for all forms of the background hormonal dysfunction of sexual sphere, but most clearly is manifested in women with the hypothalamic-hypophyseal disfunction and the polycystic degeneration of ovaries. In the basis of pathogeny of violations in the system a mother-placenta-embrion and stopping pregnancy lies inadequate immune answer for the antigens of fertile egg, low functional ability of hepatocytes, that results in the decline of adaptation mechanisms in a fetoplacentar complex. For reduction of frequency of reproduction failures, obstetric and prenatal complications the use of treatment complex with the Thiotriazolin and Kvercetin. We proposed and tested therapeutic and prophylactic applications using the combined use Thiotriazoline - Kvertsetin and have a pronounced therapeutic effect on the main pathogenetic links course miscarriage on the background of genitalia hormonal dysfunction. They are characterized by simplicity and accessibility, high clinical effectiveness, lack of side effects and complications. These arguments allow us to recommend the proposed therapies for widespread introduction into clinical practice.
Results of the study open new perspectives in the diagnosis and treatment of endocrine infertility. The level of pro- and anti-inflammatory cytokines could serve as a marker of immunological disorders that run across with subclinical endocrine infertility. The use of drugs with marked antioxidant properties of this pathology can expand indications for their use.
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Author Name: N.YATSYSHYN
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Keywords: endocrine sterility, pregnancy, immune status, placental insufficiency