Athletes and bodybuilder supplemented high protein supplements to enhance the development and strength of their muscles and obtaining a lot of energy. However, there is no available of work concerned thyroid dysfunction in men intake high proteinsupplements In the present work, we selected three animal groups of male Wistar albino rats (n=5), control, hyper whey (2.5g/kgbody weight) and super amino 2500 (2.5g/kg body weight). Daily oral intake was carried out for 14 weeks. At the end of experiment, animals were sacrificed, dissected and blood collected from puncture of heart and thyroid glands were removed. Plasma triiodothyronine (T3) and thyroxine (T4) were determined. Histopathological and histochemical investigation of glycogen and proteins were assayed. Hyper whey and super amino supplementations were found to show apparent depletion of T3 and non- significant decrease of T4 coincides with considerable atrophy and degeneration of thyroid follicles, missing of lumina colloid and marked loss of follicular epithelium. Finally the author concluded that intake of the high protein diet led to disruption of thyroid hormone parallel with histopathological abnormalities of thyroid follicles which may interfere with the reproductive function. Finally the authors concluded that high whey and super amino protein intake led to damage of thyroid follicles confirmed by depletion of T3 & T4.
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Author Name: Doaa A. Ali , Osama A Moftah , Hassan IH El-Sayyad
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Keywords: Anabolic body building protein, Thyroditis, T3&T4, Histopathology, Histochemistry of glycogen and protein.