The quantitative study of iodination of riboflavin by molecular iodine in aqueous solution at 7 pH has been studied at various temperatures. The reaction has been found to be rapid and of the second order, having a specific reaction rate 135.85 M-1s-1 at 25.3 0C. A special technique, hydrodynamic voltammetry has been used to study the rapid iodination kinetics. The energy of activation, entropy change and the frequency factor for the reaction are evaluated as 50.38 kJ, -43.08 J mol-1 K-1 and 9.01 x10 10 s-1 respectively. The kinetic and thermodynamic data obtained for this bio-active molecule are used to comment on the reactivity of the heterocycle under study on a quantitative scaffold.
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Author Name: R. R. SANGPAL, V. T. DANGAT, V. T. BORKAR, D. B. VAGARE
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Keywords: Riboflavin, Iodination, Hydrodynamic Voltammetry.