Healthy Albino Rats (Wister variety) of either sex are reared feeding on pulses, gram and bread.
After acclimatization these are divided into one normal-control and three experimental groups.
Alcoholic hepatitis is induced in two of the experimental groups by oral administration of 30%
ethanol for eight weeks. Oral administration of water- extract of Psidium guajava leaves is done
to one non-alcoholic and one alcoholic group of Rats throughout the study period. Investigation of
AST (Aspartate Transferase), ALT (Alanine Transferase), ALP (Alkaline Phosphatase) activities
in blood serum and Liver Lipid Peroxide after the experimental period leads to a conclusion that
P. guajava leaf- extract may play a good role in stopping hepatocyte destruction due to alcoholic
injury. Urea, Creatinine and Uric Acid levels in blood serum and GST (Glutathione STransferase)
and CYP (Cytochrome p450) activity in liver of the study animals indicate that no
major toxicity arise from the administration of P. guajava leaf- extract.
Real Time Impact Factor:
Pending
Author Name: S. Sarma
URL: View PDF
Keywords: Hepatopathy, alcoholism, toxicity, Albino Rats
ISSN:
EISSN: 2277 8330
EOI/DOI:
Add Citation
Views: 4283
