Introduction: Stent thrombosis, an iatrogenic disease, is an important complication of percutaneous coronary intervention (PCI). The platelet to lymphocyte ratio (PLR) has been recently proposed to be a marker of thrombosis and inflammation, mainly in cancer patients. The aim of this study was to determine whether PLR in patients presenting with acute ST elevation myocardial infarction (STEMI) is predictive of the development of stent thrombosis.
Patients and Methods: We retrospectively analyzed the clinical, hematologic, and angiographic data of total 201 patients (mean age 59.8±13.1 years, 3 out of 4 were males) who had undergone PCI for acute STEMI and a further control coronary angiography. 54 of them were diagnosed as stent thrombosis and formed the patient group and 147 patients matched with patient group in terms of age, gender, traditional coronary risk factors, stent implantation procedure, and stent type and length formed the control group in whom the stent implanted during primary PCI was found patent in the repeat coronary angiography.
Results: The pre-procedural PLR was significantly higher in patients with stent thrombosis compared to patients without stent thrombosis (176±68 vs. 135±62; p<0.001). Based on multiple logistic regression analysis, pre-procedural PLR was a significant and independent predictor of stent thrombosis (OR: 1.009, 95% confidence interval: 1.004-1.014, p<0.001). Using a receiver operating characteristics (ROC) analysis, a PLR > 150 had 63% sensitivity and 70% specificity for predicting stent thrombosis (ROC area under curve: 0.692, 95% CI: 0.614- 0.771, p<0.001).
Conclusion: A high pre-procedural PLR is a significant and independent predictor of stent thrombosis in patients with acute STEMI.
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Author Name: Mustafa Oylumlu, Abdülkadir Y?ld?z, Murat Yüksel, Ahmet Korkmaz, Mesut Ayd?n, Mehmet Zihni Bilik, Mehmet Ata Ak?l, S?dd?k Ülgen
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Keywords: Percutaneous coronary intervention, platelet to lymphocyte ratio; ST elevation myocardial infarction; stent thrombosis
ISSN: 13008706
EISSN:
EOI/DOI: 10.4274/khj.88597
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