A Comparative Study ofAmphotericinB Versus Miltefosine Regarding Efficacy and safety profile in Pediatric Cases of Visceral Leishmaniasis

From the treatment point of view many drugs have been tried with various efficacyin visceral leishmaniasis.Objectives:The study was undertaken to compare the efficacy of intravenous amphotericin B and oral miltefosine in the treatment of visceral leishmaniasis in children. Materials and methods: In this study 60 consecutive diagnosed cases of kalaazar were studied in pediatric indoor ward of J.L.N. Medical College & Hospital Bhagalpur. All thecases included in study, randomly divided into two groups A and B with equal no. of patients (30 in each) in both groups. Patients of group A were given intravenous Amphotericin B in the dose schedule of 1mg/kgon alternate day for 15 doses. Patients of group B were given oral miltefosine in dose schedule of 2.5mg /kg daily for 28 days.During the therapy, clinical and parasitological response and safety profiles of the drugs in both groups were closely monitored. Conclusion: " Both the drugs i.e. Amphotericin B as well as Miltefosine had been observed as equally efficacious in causing clinical as well as parasitological cure in pediatric cases of visceral leishmaniasis and no sufficient toxicity developed in either group and so they are equally safe in children "

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Keywords: Visceral leishmaniasis , Kala-azar , Amphotericin B , Miltefosine.

ISSN: 2320-5407

EISSN: 2320-5407


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