The paper is devoted to the study of the possibility of using the general nonspecific adaptive reactions
of organism as a criterion for the threshold at hygienic regulation of harmful chemical compounds and as a crite-
rion for prenosological states of the workers’ organism in the conditions of chemical production. As the method-
ology of determination of the general nonspecific adaptive reactions (GNAR) served the analysis of the ratio of
formed elements white blood cells, accordingly them there were distinguished: reaction training, calm and in-
creased activation, over activation, acute and chronic stress. By comparing the sensitivity of GNAR and clinical-
laboratory parameters used to establish the threshold of chronic action of the 18 chemical compounds related to
the different chemical classes, found out that from 10 to 50 % of the cases of changes in organism of the experi-
mental animals, considered as threshold, they were accompanied by development of the pathological GNAR
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Author Name: T. V. Zhukova, S. N. Belik, O. A. Svintukhovsky, I. M. Kharagurgieva, N. A. Kononenko
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Keywords: general nonspecific adaptive response; threshold of chronic effects; primary prevention of diseases
ISSN: 2336-2642
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