Background: Rate of mortality due to cardiovascular diseases is high in Maintenance
Hemodialysis (MHD) patients. Additionally, prolonged QT interval is reportedly
associated with high-risk ventricular arrhythmia and sudden death. Vascular calcification
may be related to QT dispersion interval in MHD patients because the extensive nature
of the calcification process may involve the conducting system and myocardium.
Objectives: This study aimed to evaluate the relationship between QT interval and Pulse
Wave Velocity (PWV) as a sign of arterial stiffness associated with atherosclerosis in
Patients and Methods: This prospective, observational study was conducted on 149
eligible MHD patients for 12 months. Patients using drugs known to affect QT interval
were excluded. The patients were divided into four groups as follows: normal corrected
QT (QTc) interval at the beginning and end of the study (n = 44, 29.5%), normal QTc
interval at the beginning but prolonged QTc interval at the end of the study (n = 30,
20.1%), prolonged QTc interval at the beginning but normal QTc interval at the end of
the study (n = 24, 16.1%), and prolonged QTc interval at the beginning and end of the
study (n = 51, 34.2%). Demographic parameters, laboratory parameters, and PWV were
assessed at the beginning and the 12th month of the study. Then, the data were analyzed
using ANOVA or Pearson 2 test and P < 0.05 was considered to be statistically significant.
Results: The study groups were similar with respect to age and comorbidities, including
diabetes mellitus, hypertension, and dyslipidemia. In addition, there were no significant
differences among the groups regarding the initial PWV (P = 0.412); however, the ending
PWV showed significant differences (P = 0.029). The results of multivariate analysis
showed that PWV was independently associated with change in the maximum QTc
(confidence interval: 0.039 – 1.787, P = 0.031, ? = 0.178).
Conclusions: The results suggested inclusion of QTc interval prolongation, as a predictor of
cardiovascular disease, either alone or in combination with PWV in such high-risk patients.
Real Time Impact Factor:
Author Name: Zeynep Bal 1, *, Ugur Bal 2, Suleyman Karakose 3, Emre Tutal 1, Mehtap Erkmen Uyar 1, Siren Sezer 1
URL: View PDF
Keywords: Vascular Stiffness,Chronic Kidney Disease