Objective: The objective of this study was to find out (if any) association between ki67 proliferative marker expression
with COX2 and iNOS immuonoreactivity in bladder cancer.
Methodology: The present study investigated the relationship between immunohistochemical expression of ki67, COX2
and iNOS in bladder carcinomas in serial paraffin sections from 155 bladder carcinomas. Thirty nine control cases of
benign bladder cystitis lesions were included.
Results: Significant difference in the expression of all selected markers between carcinomas and cystitis was observed
(p.value = 0.000). Ki67 immuonoreactivity associated significantly with both COX2 and iNOS intensity, denoting P values
of (0.000) with both markers among bladder carcinomas.
Conclusion: Strong link between proliferative markers (Ki67), COX2 and iNOS were detected among bladder
carcinomas. Thus the three investigated markers (ki67, COX2 and iNOS) can be used as pre-warning factors of bladder
cancers among patients at risk of bladder cancer.
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Author Name: Hassan Elsiddig Hassan FARAGALLA1,2 , Hussain Gadelkarim AHMED3, Faris Mohammednour ALTAF4,5 and Ashraf Mohamed Elsayed Ali SAKRAN4
URL: View PDF
Keywords: ki67, COX2, iNOS, Bladder cancer.
ISSN: 2456-1045
EISSN: 2456-1045
EOI/DOI:
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